Ferrous Glycinate

Description

Discussion

Ferrous iron is reacted with glycine to form bis-glycinate chelate, a non-electrically charged compound that is totally nutritionally functional. The absence of electrical charge, uncommon for an iron supplement, makes it less likely that Ferrous Glycinate can interfere with absorption of other minerals such as calcium, vitamin E or vitamin C. Iron solubility from iron bis-glycine chelate is not affected by pH changes from 2-6. This means it travels unchanged through the stomach, into the intestine, where it is absorbed and released for transport throughout the body.*

Patient compliance with iron bis-glycinate appears to be better than that seen with inorganic forms of iron supplements for two reasons. First, the taste: In a study with 145 pregnant women (that concluded daily supplementation with iron bis-glycinate chelate was significantly more effective even at a lower dose than ferrous sulfate) the percentage of taste complaints among the women given ferrous sulfate was 29.8%, while 0% of the women on the bis-glycinate chelate complained about taste. Second, iron bis-glycinate is less likely to have any of the gastrointestinal side-effects associated with standard iron supplementation.*

A published absorption study showed there was a significant correlation between iron absorption of iron bisglycinate chelate to serum ferritin (r = -0.60, p < 0.03) (The higher the ferritin the lower the absorption and vice versa.) The amount of iron stored in the body regulates iron bis-glycinate chelate absorption. This translates into less chance of toxicity. Another benefit of the bis-glycinate chelate form of iron over other iron supplements is that it doesn’t act as a pro-oxidant.*

Iron is an important component of hemoglobin, myoglobin, and ferritin. These proteins are involved in the transport, storage, and release of oxygen to the tissues.*

References

1. Pineda O, Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition. 2001 May;17(5):381-4. [PMID:11377130]
2. Szarfarc SC, de Cassana LM, Fujimori E, Guerra-Shinohara EM, de Oliveira IM. Relative effectiveness of iron bis-glycinate chelate (Ferrochel) and ferrous sulfate in the control of iron deficiency in pregnant women. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):42-7 [PMID: 1688081]
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11. Szarfarc SC, de Cassana LM, Fujimori E, Guerra-Shinohara EM, de Oliveira IM. Relative effectiveness of iron bis-glycinate chelate (Ferrochel) and ferrous sulfate in the control of iron deficiency in pregnant women. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):42-7 [PMID: 11688081]
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